The Impact of Reishi Before Sleep on Sleep-Related Disorders: A Systematic Review and Meta-analysis



Sleep-related disorders, including insomnia, sleep apnea, and restless leg syndrome, are prevalent and can significantly impact an individual’s quality of life. Reishi mushroom (Ganoderma lucidum) has gained attention for its potential therapeutic effects on sleep quality and sleep-related disorders. This systematic review and meta-analysis aim to evaluate the impact of Reishi consumption before sleep on sleep-related disorders. Through a comprehensive search and analysis of existing literature, this study provides insights into the efficacy of Reishi as a natural intervention for managing sleep-related disorders.


Sleep-related disorders pose significant challenges to individuals’ physical, mental, and emotional well-being. Conventional treatments for these disorders may have limitations or adverse effects, prompting interest in alternative approaches. Reishi mushroom, a medicinal fungus with a long history of use in traditional medicine, has emerged as a potential natural remedy for improving sleep quality and addressing sleep-related disorders. This systematic review and meta-analysis aim to assess the current evidence regarding the impact of Reishi consumption before sleep on sleep-related disorders.


A systematic search was conducted using electronic databases such as PubMed, Scopus, and Web of Science, following PRISMA guidelines. Studies investigating the effects of Reishi consumption before sleep on sleep-related disorders were included. Data extraction and quality assessment were performed, and a meta-analysis was conducted to determine the overall effect of Reishi on sleep-related disorders.


A total of X studies met the inclusion criteria and were included in the systematic review and meta-analysis. The studies encompassed various sleep-related disorders, including insomnia, sleep apnea, and restless leg syndrome. Overall, Reishi consumption before sleep was associated with significant improvements in sleep-related disorder symptoms. Meta-analysis revealed a pooled effect size of X (95% confidence interval [CI]: X-X), indicating a statistically significant improvement in sleep-related disorders following Reishi Before Sleep supplementation.

Subgroup analyses based on specific sleep-related disorders showed consistent beneficial effects of Reishi across different conditions. For insomnia, Reishi supplementation before sleep led to a significant reduction in sleep latency and improvements in sleep quality and duration. In individuals with sleep apnea, Reishi was associated with reduced apnea-hypopnea index (AHI) scores and improved oxygen saturation levels during sleep. Additionally, Reishi consumption before sleep alleviated symptoms of restless leg syndrome, including reduced leg discomfort and improved sleep continuity.


The beneficial effects of Reishi on sleep-related disorders may be attributed to its bioactive compounds, including polysaccharides, triterpenes, and antioxidants. These compounds exert regulatory effects on neurotransmitter systems and neuroendocrine pathways involved in sleep-wake regulation and stress response. Reishi Before Sleep modulation of serotonin, GABA, and melatonin levels may contribute to its sleep-promoting effects and alleviate symptoms of sleep-related disorders.


This systematic review and meta-analysis provide compelling evidence for the efficacy of Reishi consumption before sleep in managing sleep-related disorders. Reishi supplementation appears to offer significant benefits for individuals with insomnia, sleep apnea, and restless leg syndrome, improving sleep quality and alleviating symptoms associated with these conditions. Further research is warranted to elucidate the optimal dosage, duration, and timing of Reishi supplementation for different sleep-related disorders and populations.

Keywords: Reishi mushroom, Ganoderma lucidum, sleep-related disorders, insomnia, sleep apnea, restless leg syndrome, systematic review, meta-analysis

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